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ACAT-1 Polyclonal Antibody, 100μg, (ATB-T0071)

$199.00
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Background: This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]Product datasheet: Overview Product Description ACAT-1 Polyclonal Antibody, 100μg, (ATB-T0071) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human ACAT-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance. Shibuya Y, et al. J Neurosci, 2014 Oct 22. PMID 25339759 Association between single nucleotide polymorphism rs1044925 and the risk of coronary artery disease and ischemic stroke. Wu DF, et al. Int J Mol Sci, 2014 Feb 26. PMID 24577316 Free PMC Article Acyl-coenzyme A:cholesterol acyltransferase 1 - significance of single-nucleotide polymorphism at residue 526 and the role of Pro347 near the fifth transmembrane domain. Huang LH, et al. FEBS J, 2014 Apr. PMID 24517390 Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1. Yamanaka K, et al. Cell Death Dis, 2014 Jan 9. PMID 24407243 Free PMC Article Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression. Saraon P, et al. Prostate, 2014 Apr. PMID 24311408

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ACAT-1 Polyclonal Antibody, 100μg, (ATB-T0071)
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