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AChRβ1 Polyclonal Antibody, 100μg, (ATB-T0084)

$199.00
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Product Details

Background: The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description AChRβ1 Polyclonal Antibody, 100μg, (ATB-T0084) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human AChRβ1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Mutation causing congenital myasthenia reveals acetylcholine receptor beta/delta subunit interaction essential for assembly. Quiram PA, et al. J Clin Invest, 1999 Nov. PMID 10562302 Free PMC Article A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome. Gomez CM, et al. Ann Neurol, 1996 Jun. PMID 8651643 Nucleotide sequence of human muscle acetylcholine receptor beta-subunit. Beeson D, et al. Nucleic Acids Res, 1989 Jun 12. PMID 2740233 Free PMC Article Research methods in the biomechanics of sports. Kraus H. Orthop Clin North Am, 1977 Jul. PMID 887246 Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions. Lee WY, et al. J Neurosci, 2009 Mar 11. PMID 19279256 Free PMC Article

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AChRβ1 Polyclonal Antibody, 100μg, (ATB-T0084)
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