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ADAMTS-17 Polyclonal Antibody, 100μg, (ATB-T0115)

$199.00
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Product Details

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description ADAMTS-17 Polyclonal Antibody, 100μg, (ATB-T0115) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human ADAMTS-17. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Whole exome sequencing identifies a novel splice-site mutation in ADAMTS17 in an Indian family with Weill-Marchesani syndrome. Shah MH, et al. Mol Vis, 2014. PMID 24940034 Free PMC Article Familial spherophakia with short stature caused by a novel homozygous ADAMTS17 mutation. Khan AO, et al. Ophthalmic Genet, 2012 Dec. PMID 22486325 Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Morales J, et al. Am J Hum Genet, 2009 Nov. PMID 19836009 Free PMC Article Genome-wide association study identifies two susceptibility loci for osteosarcoma. Savage SA, et al. Nat Genet, 2013 Jul. PMID 23727862 Free PMC Article Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. Boulaftali Y, et al. Arterioscler Thromb Vasc Biol, 2013 Jul. PMID 23661674

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ADAMTS-17 Polyclonal Antibody, 100μg, (ATB-T0115)
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