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ALK-1 Polyclonal Antibody, 100μg, (ATB-T0198)

$199.00
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Background: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description ALK-1 Polyclonal Antibody, 100μg, (ATB-T0198) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human ALK-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. Chen HW, et al. Biochim Biophys Acta, 2013 Dec. PMID 24189493 An intron mutation in the ACVRL1 may be associated with a transcriptional regulation defect in a Chinese family with hereditary hemorrhagic telangiectasia. Yu Q, et al. PLoS One, 2013. PMID 23460919 Free PMC Article The expression of activin receptor-like kinase 1 among patients with head and neck cancer. Chien CY, et al. Otolaryngol Head Neck Surg, 2013 Jun. PMID 23447486 Retention in the endoplasmic reticulum is the underlying mechanism of some hereditary haemorrhagic telangiectasia type 2 ALK1 missense mutations. Hume AN, et al. Mol Cell Biochem, 2013 Jan. PMID 23124896 Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties. Mahlawat P, et al. Biochemistry, 2012 Aug 14. PMID 22799562 Free PMC Article

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ALK-1 Polyclonal Antibody, 100μg, (ATB-T0198)
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