AR α2C Polyclonal Antibody, 100µg, (ATB-T0300)

Background: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.Product datasheet: Overview Product Description AR α2C Polyclonal Antibody, 100µg, (ATB-T0300) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human AR α2C. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Regan J.W., Kobilka T.S., Yang-Feng T.L., Caron M.G., Lefkowitz R.J., Kobilka B.K.Proc. Natl. Acad. Sci. U.S.A. 85:6301-6305(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene. Schaak S., Devedjian J.C., Cayla C., Sender Y., Paris H.Biochem. J. 328:431-438(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain. Molecular cloning and expression of a novel human alpha2C-adrenerginc receptor, alpha2CII, gene. Yano K., Takeda M., Sugimoto E., Sagai H.Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. Small K.M., Forbes S.L., Rahman F.F., Bridges K.M., Liggett S.B.J. Biol. Chem. 275:23059-23064(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT 322-GLY--PRO-325 DEL. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Small K.M., Mialet-Perez J., Seman C.A., Theiss C.T., Brown K.M., Liggett S.B.Proc. Natl. Acad. Sci. U.S.A. 101:13020-13025(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT 322-GLY--PRO-325 DEL. Isolation of complete coding sequence for adrenergic receptor alpha 2C (ADRA2C). Kopatz S.A., Aronstam R.S., Sharma S.V.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT 322-GLY--PRO-325 DEL. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. Chhajlani V., Rangel N., Uhlen S., Wikberg J.E.S.FEBS Lett. 280:241-244(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-223.