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AR-α1A Polyclonal Antibody, 100μg, (ATB-T0354)

$199.00
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Product Details

Background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description AR-α1A Polyclonal Antibody, 100μg, (ATB-T0354) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human AR-α1A. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Upregulation of α1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II. Drummond PD, et al. Pain, 2014 Mar. PMID 24342464 Association of the ADRA1A gene and the severity of metabolic abnormalities in patients with schizophrenia. Cheng C, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2012 Jan 10. PMID 22037178 α-1 Adrenergic receptor signaling linked to memory dysfunction following brain trauma. Tomycz ND, et al. Neurosurgery, 2011 Apr. PMID 21792097 α1A-adrenergic receptor induces activation of extracellular signal-regulated kinase 1/2 through endocytic pathway. Liu F, et al. PLoS One, 2011. PMID 21738688 Free PMC Article Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population. Grassi G, et al. J Hypertens, 2011 Jun. PMID 21519279

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AR-α1A Polyclonal Antibody, 100μg, (ATB-T0354)
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