AR α2A Polyclonal Antibody, 100µg, (ATB-T0298)

Background: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.Product datasheet: Overview Product Description AR α2A Polyclonal Antibody, 100µg, (ATB-T0298) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human AR α2A. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Kobilka B.K., Matsui H., Kobilka T.S., Yang-Feng T.L., Francke U., Caron M.G., Lefkowitz R.J., Regan J.W.Science 238:650-656(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE. Tissue: Platelet. Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation. Fraser C.M., Arakawa S., McCombie W.R., Venter J.C.J. Biol. Chem. 264:11754-11761(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. Guyer C.A., Horstman D.A., Wilson A.L., Clark J.D., Kragoe E.J. Jr., Limbird L.E.J. Biol. Chem. 265:17307-17317(1990) [PubMed] [Europe PMC] Cited for: SEQUENCE REVISION TO 333-365. An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. Small K.M., Forbes S.L., Brown K.M., Liggett S.B.J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-251. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression. Small K.M., Brown K.M., Seman C.A., Theiss C.T., Liggett S.B.Proc. Natl. Acad. Sci. U.S.A. 103:5472-5477(2006) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-251. Cloning and expression of human alpha-2A adrenergic receptor in SY5Y cells. Mao Z.-M., Tang K., Li B.-M., Jing N.-H.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. A search for genetic variability in the human alpha-2 adrenergic receptor on chromosome 10. Castellano M., Giacche' M., Rossi F., Rivadossi F., Perani C., Beschi M., Agabiti Rosei E.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Human alpha-2A adrenergic receptor gene and the genotype of -1296 nucleotide and motionsickness. Liu L., Yuan L.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. SeattleSNPs variation discovery resourceSubmitted (NOV-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-251. NHLBI resequencing and genotyping service (RS&G)Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].