AVP Receptor V2 Polyclonal Antibody, 100μg, (ATB-T0423)

Background: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description AVP Receptor V2 Polyclonal Antibody, 100μg, (ATB-T0423) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human AVP Receptor V2. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Characterization of the effects of the vasopressin V2 receptor on sweating, fluid balance, and performance during exercise. Hew-Butler T, et al. Am J Physiol Regul Integr Comp Physiol, 2014 Aug 15. PMID 24944242 Altered agonist sensitivity of a mutant v2 receptor suggests a novel therapeutic strategy for nephrogenic diabetes insipidus. Erdélyi LS, et al. Mol Endocrinol, 2014 May. PMID 24628417 Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again. Rinschen MM, et al. J Am Soc Nephrol, 2014 Jun. PMID 24556353 A large deletion of the AVPR2 gene causing severe nephrogenic diabetes insipidus in a Turkish family. Saglar E, et al. Endocrine, 2014 May. PMID 24026507 Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). Armstrong SP, et al. PLoS One, 2013. PMID 23762448 Free PMC Article