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AbinScience InVivoMAb Anti-Human Gremlin Antibody (Iv0131) (HT246010-1MG)
Overview
| Catalog No. | HT246010-1MG |
|---|---|
| Description | AbinScience InVivoMAb Anti-Human GREM1/DAND2 Antibody (Iv0131)[Iv0131] (HT246010-1MG) is a human monoclonal
antibody detecting Cysteine knot superfamily 1
in ELISA, FCM, Neutralization. Suitable for Human.
HIGHLIGHTS
|
| Species reactivity | Human |
| Applications | ELISA, FCM, Neutralization |
| Host species | Human |
| Isotype | IgG4, kappa |
| Clone ID | Iv0131 |
| Clonality | Monoclonal |
| Target | Cysteine knot superfamily 1, BMP antagonist 1, CKTSF1B1, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, DRM, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, DAND2 |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | O60565 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Gremlin-1 (GREM1/DAND2) is a ~20 kDa protein. Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. 1. Kišonaitė, M. et al. (2016) The Biochemical journal 473, 1593-604. PMID: 27036124
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
Flow-cytometry using anti-human GREM1 antibody.GREM1 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human GREM1 antibody monoclonal antibody (Catalog # HT246010 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE for InVivoMAb Anti-Human GREM1/DAND2 Antibody (Iv0131).