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AbinScience InVivoMAb Anti-Human IFN-beta Antibody (Iv0199) (HF855010-50UG)
Overview
| Catalog No. | HF855010-50UG |
|---|---|
| Description | AbinScience InVivoMAb Anti-Human IFNB1/IFN-beta Antibody (Iv0199)[Iv0199] (HF855010-50UG) is a human monoclonal
antibody detecting Interferon beta
in ELISA, Neutralization. Suitable for Human.
|
| Species reactivity | Human |
| Applications | ELISA, Neutralization |
| Host species | Human |
| Isotype | IgG1, kappa |
| Clone ID | Iv0199 |
| Clonality | Monoclonal |
| Target | Interferon beta, IFN-beta, Fibroblast interferon, IFNB1, IFB, IFNB |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P01574 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Interferon beta (IFNB1/IFN-beta) is a ~22 kDa protein. Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. 1. Russell-Harde, D. et al. (1999) Biochemical and biophysical research communications 255, 539-44. PMID: 10049744
2. Piehler, J. et al. (1999) Journal of molecular biology 294, 223-37. PMID: 10556041
3. Derynck, R. et al. (1980) Nature 285, 542-7. PMID: 6157094
4. Shepard, HM. et al. (1981) Nature 294, 563-5. PMID: 6171735
5. Domanski, P. et al. (1995) The Journal of biological chemistry 270, 21606-11. PMID: 7665574
6. Platanias, LC. et al. (1994) The Journal of biological chemistry 269, 17761-4. PMID: 8027027
7. Croze, E. et al. (1996) The Journal of biological chemistry 271, 33165-8. PMID: 8969169
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Human IFNB1/IFN-beta Antibody (Iv0199).
Datasheets
InVivoMAb Anti-Human IFN-beta Antibody (Iv0199).pdf