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AbinScience InVivoMAb Anti-Human M-CSF R/CD115 Antibody (H27K15) (HY035010-50UG)
Overview
| Catalog No. | HY035010-50UG |
|---|---|
| Description | AbinScience InVivoMAb Anti-Human CD115/CSF1R Antibody (H27K15)[H27K15] (HY035010-50UG) is a human monoclonal
antibody detecting CD115
in ELISA, FCM, FuncS. Suitable for Human.
HIGHLIGHTS
|
| Species reactivity | Human |
| Applications | ELISA, FCM, FuncS |
| Host species | Human |
| Isotype | IgG1 |
| Clone ID | H27K15 |
| Clonality | Monoclonal |
| Target | CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P07333 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. 1. Wei, S. et al. (2010) Journal of leukocyte biology 88, 495-505. PMID: 20504948
2. Guo, L. et al. (2019) American journal of human genetics 104, 925-935. PMID: 30982609
3. Oosterhof, N. et al. (2019) American journal of human genetics 104, 936-947. PMID: 30982608
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Human CD115/CSF1R Antibody (H27K15)
Detects CD115 in indirect ELISA.
Western blot analysis was performed using anti-CD115/CSF1R monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD115/CSF1R (Catalog No: HY035011)
Lane 2: negative control
Datasheets
InVivoMAb Anti-Human M-CSF R/CD115 Antibody (H27K15).pdf