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AbinScience InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0195) (VK623010-1MG)

AbinScience InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0195) (VK623010-1MG)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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Product Details

Overview

Catalog No. VK623010-1MG
Description
AbinScience InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0195)[Iv0195] (VK623010-1MG) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA, Neutralization. Suitable for Zaire ebolavirus.
Species reactivity Zaire ebolavirus
Applications ELISA, Neutralization
Host species Human
Isotype IgG1, kappa
Clone ID Iv0195
Clonality Monoclonal
Target Envelope glycoprotein, GP1, 2, GP, Shed GP, GP1, 2-delta, GP1, GP2, GP
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession Q05320
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430
2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476
3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576
4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549
5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900
6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924
7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839
8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074
Note For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE for InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0195).

Datasheets

InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0195).pdf

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AbinScience InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0195) (VK623010-1MG)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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