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Abinscience Anti-Human ADAMTS5 Recombinant Antibody (12F4) (HV374013-50ug)

Abinscience Anti-Human ADAMTS5 Recombinant Antibody (12F4) (HV374013-50ug)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / Antibodies for Biomarkers
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Product Details

Overview

Catalog No. HV374013-50ug
Species reactivity Human
Applications ELISA, Neutralization
Host species Mouse
Isotype IgG1
Clone ID 12F4
Clonality Monoclonal
Target ADAMTS5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, ADAMTS11, ADAM-TS 11, ADAMTS-11, ADMP2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 5, A disintegrin and metalloproteinase with thrombospondin motifs 11, Aggrecanase-2
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Associated products pH 7.4 Dilution Buffer
Purification Protein A/G purified from cell culture supernatant.
Accession Q9UNA0
RRID Anti-Human ADAMTS5 Antibody (12F4) (abinScience Cat# HV374013, RRID:AB_3725375)
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:2000-1:20000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a ~101 kDa protein. Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.

1. Nakada, M. et al. (2005) Acta neuropathologica 110, 239-46. PMID: 16133547
2. Longpré, JM. et al. (2009) The international journal of biochemistry & cell biology 41, 1116-26. PMID: 18992360
Note For research use only.

Images

SDS-PAGE for Anti-Human ADAMTS5 Antibody (12F4).

Datasheets

Anti-Human ADAMTS5 Recombinant Antibody (12F4).pdf


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Abinscience Anti-Human ADAMTS5 Recombinant Antibody (12F4) (HV374013-50ug)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / Antibodies for Biomarkers
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