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Abinscience Anti-Human APP Recombinant Antibody (21F12) (HP849013)
Overview
| Catalog No. | HP849013 | ||||||
|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||
| Applications | ELISA, IHC, WB | ||||||
| Host species | Mouse | ||||||
| Isotype | IgG1 | ||||||
| Clone ID | 21F12 | ||||||
| Clonality | Monoclonal | ||||||
| Target | Abeta42, Beta-APP42, Amyloid-beta protein 42, amyloid beta A4 precursor protein, Amyloid-beta A4 protein | ||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||
| Purity | >95% as determined by SDS-PAGE. | ||||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||||
| Accession | P05067 | ||||||
| Form | Liquid | ||||||
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| Background | Amyloid-beta precursor protein (Abeta 42/Beta-APP 42) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. 1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912
2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754
3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729
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| Note | For research use only. |
Images
SEC-HPLC detection for Anti-Human Abeta42/Beta-APP42 Antibody (21F12).
SDS-PAGE for Anti-Human Abeta42/Beta-APP42 Antibody (21F12).