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Abinscience Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)

Abinscience Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / Antibodies for Alzheimer disease
$196.00
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Product Details

Overview

Catalog No. HW641013
Description
Abinscience Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782)(HW641013) is a mouse monoclonal antibody detecting PSEN1/Presenilin-1 in ELISA. Suitable for Human.
HIGHLIGHTS
  • ● Affinity Purified — Minimal background and high purity for reliable results.
Species reactivity Human
Applications ELISA
Host species Mouse
Clonality Monoclonal
Isotype IgG2a, kappa
Clone ID SAA1782
Target PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1
Endotoxin level < 10 EU/mg as determined by LAL method.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P49768
RRID Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) (abinScience Cat# HW641013, RRID:AB_3727544)
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:2000-1:20000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background

Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1.

1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644
2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183
3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 10593990
4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883
5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933
6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784
7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439
8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632
9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383
10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039
Note For research use only.

Images

SDS-PAGE for Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)

Datasheets

Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782).pdf


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Abinscience Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / Antibodies for Alzheimer disease
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