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Abinscience InVivoMAb Anti-Canine TNF-alpha Antibody (Iv0271) (CF879010-1mg)
Overview
| Catalog No. | CF879010-1mg |
|---|---|
| Description | Abinscience InVivoMAb Anti-Dog TNFa/TNF-alpha Antibody (Iv0271)[Iv0271] (CF879010-1mg) is a dog monoclonal
antibody detecting TNF
in Blocking, ELISA, FCM. Suitable for Dog.
HIGHLIGHTS
|
| Species reactivity | Dog |
| Applications | Blocking, ELISA, FCM |
| Host species | Canine |
| Isotype | IgG1, kappa |
| Clone ID | Iv0271 |
| Clonality | Monoclonal |
| Target | TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1 |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P51742 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Tumor necrosis factor (TNFa/TNF-alpha) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. TNFa is the therapeutic target of adalimumab (Humira). |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Dog TNFa/TNF-alpha Antibody (Iv0271)
Detects recombinant dog TNFa/TNF-alpha (Catalog No: CF879011) in indirect ELISA
Datasheets
InVivoMAb Anti-Canine TNF-alpha Antibody (Iv0271).pdf