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Abinscience InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242) (VK425010-50ug)
Overview
| Catalog No. | VK425010-50ug |
|---|---|
| Description | Abinscience InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242)[m242] (VK425010-50ug) is a human monoclonal
antibody detecting Structural polyprotein
in ELISA, Neutralization. Suitable for Chikungunya virus.
|
| Species reactivity | Chikungunya virus |
| Applications | ELISA, Neutralization |
| Host species | Human |
| Isotype | IgG1 |
| Clone ID | m242 |
| Clonality | Monoclonal |
| Target | Structural polyprotein, p130, Capsid protein, 3.4.21.90, Coat protein, C, Precursor of protein E3/E2, p62, pE2, Assembly protein E3, Spike glycoprotein E2, E2 envelope glycoprotein, 6K protein, Spike glycoprotein E1, E1 envelope glycoprotein |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | Q8JUX5, Q1H8W5, Q5XXP3 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Structural polyprotein (VLP) is a ~138 kDa protein. Forms an icosahedral capsid with a T=4 symmetry composed of 240 copies of the capsid protein surrounded by a lipid membrane through which penetrate 80 spikes composed of trimers of E1-E2 heterodimers. The capsid protein binds to the viral RNA genome at a site adjacent to a ribosome binding site for viral genome translation following genome release. Possesses a protease activity that results in its autocatalytic cleavage from the nascent structural protein. Following its self-cleavage, the capsid protein transiently associates with ribosomes, and within several minutes the protein binds to viral RNA and rapidly assembles into icosahedric core particles. The resulting nucleocapsid eventually associates with the cytoplasmic domain of the spike glycoprotein E2 at the cell membrane, leading to budding and formation of mature virions. 1. Webb, LG. et al. (2020) PLoS pathogens 16, e1008999. PMID: 33057424
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242)
Datasheets
InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242).pdf