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Abinscience InVivoMAb Anti-HAV Capsid protein VP2 Antibody (R10) (VK802010-50ug)

Abinscience InVivoMAb Anti-HAV Capsid protein VP2 Antibody (R10) (VK802010-50ug)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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Product Details

Overview

Catalog No. VK802010-50ug
Description
Abinscience InVivoMAb Anti-HAV Capsid protein VP2 Antibody (R10)[R10] (VK802010-50ug) is a human monoclonal antibody detecting Genome polyprotein in ELISA, Neutralization.
Species reactivity Human hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A virus (isolate Human/Australia/HM175/1976))
Applications ELISA, Neutralization
Host species Human
Isotype IgG1
Clone ID R10
Clonality Monoclonal
Target Genome polyprotein, Capsid protein VP2, P1B, Virion protein 2
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P08617
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Genome polyprotein (Capsid protein VP2) is a ~251 kDa protein. Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome. All these proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. The naked capsid interacts with the host receptor HAVCR1 to provide virion attachment to and probably entry into the target cell.

1. Wang, X. et al. (2015) Nature 517, 85-88. PMID: 25327248
2. Wang, X. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 770-775. PMID: 28074040
3. Silberstein, E. et al. (2001) Journal of virology 75, 717-25. PMID: 11134285
4. Costafreda, MI. et al. (2018) Journal of virology 92. PMID: 29437974
5. Feigelstock, D. et al. (1998) Journal of virology 72, 6621-8. PMID: 9658108
Note For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE for InVivoMAb Anti-HAV Capsid protein VP2 Antibody (R10)

Datasheets

InVivoMAb Anti-HAV Capsid protein VP2 Antibody (R10).pdf


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Abinscience InVivoMAb Anti-HAV Capsid protein VP2 Antibody (R10) (VK802010-50ug)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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