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Abinscience InVivoMAb Anti-Human Angiopoietin-like Protein 3/ANGPTL3 Antibody (Iv0160) (HV176010-50ug)
Overview
| Catalog No. | HV176010-50ug |
|---|---|
| Description | Abinscience InVivoMAb Anti-Human ANGPTL3 Antibody (Iv0160)[Iv0160] (HV176010-50ug) is a human monoclonal
antibody detecting ANG-5
in ELISA, Neutralization. Suitable for Human, Mouse, and Rat.
HIGHLIGHTS
|
| Species reactivity | Human, Mouse, Rat |
| Applications | ELISA, Neutralization |
| Host species | Human |
| Isotype | IgG4, kappa |
| Clone ID | Iv0160 |
| Clonality | Monoclonal |
| Target | ANG-5, Angiopoietin-like protein 3, ANGPT5, Angiopoietin-5, ANGPTL3, Angiopoietin-related protein 3 |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Associated products | pH 7.4 Dilution Buffer |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | Q9Y5C1 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Angiopoietin-related protein 3 (ANGPTL3) is a ~53 kDa protein. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. 1. Koishi, R. et al. (2002) Nature genetics 30, 151-7. PMID: 11788823
2. Ono, M. et al. (2003) The Journal of biological chemistry 278, 41804-9. PMID: 12909640
3. Robciuc, MR. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 1706-13. PMID: 23661675
4. Tikka, A. et al. (2014) Bioscience reports 34, e00160. PMID: 25495645
5. Shimizugawa, T. et al. (2002) The Journal of biological chemistry 277, 33742-8. PMID: 12097324
6. Lee, EC. et al. (2009) The Journal of biological chemistry 284, 13735-13745. PMID: 19318355
7. Liu, J. et al. (2010) The Journal of biological chemistry 285, 27561-70. PMID: 20581395
8. Shimamura, M. et al. (2007) Arteriosclerosis, thrombosis, and vascular biology 27, 366-72. PMID: 17110602
9. Shan, L. et al. (2009) The Journal of biological chemistry 284, 1419-24. PMID: 19028676
10. Shimamura, M. et al. (2003) Biochemical and biophysical research communications 301, 604-9. PMID: 12565906
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Human ANGPTL3 Antibody (Iv0160).
Datasheets
InVivoMAb Anti-Human Angiopoietin-like Protein 3/ANGPTL3 Antibody (Iv0160).pdf