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Abinscience InVivoMAb Anti-Human Apolipoprotein E/ApoE Antibody (HJ15.1) (HF739020-50ug)
Overview
| Catalog No. | HF739020-50ug |
|---|---|
| Description | Abinscience InVivoMAb Anti-Human APOE4 Antibody (HJ15.1)[HJ15.1] (HF739020-50ug) is a mouse monoclonal
antibody detecting Apo-E
in ELISA, FuncS. Suitable for Human.
|
| Species reactivity | Human |
| Applications | ELISA, FuncS |
| Host species | Mouse |
| Isotype | IgG2a, kappa |
| Clone ID | HJ15.1 |
| Clonality | Monoclonal |
| Target | Apo-E, Apolipoprotein E, APOE |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P02649 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Apolipoprotein E (APOE4) is a ~36 kDa protein. APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. 1. Krimbou, L. et al. (2004) Journal of lipid research 45, 839-48. PMID: 14754908
2. Arnon, R. et al. (1991) Biochimica et biophysica acta 1085, 336-42. PMID: 1911868
3. Marcel, YL. et al. (1983) Biochimica et biophysica acta 750, 411-7. PMID: 6860692
4. Sehayek, E. et al. (1991) The Journal of biological chemistry 266, 18259-67. PMID: 1917954
5. Verghese, PB. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, E1807-16. PMID: 23620513
6. Kowal, RC. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 5810-4. PMID: 2762297
7. Ji, ZS. et al. (1997) The Journal of biological chemistry 272, 31285-92. PMID: 9395455
8. Li, X. et al. (2003) Biochemistry 42, 10406-17. PMID: 12950167
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Human APOE4 Antibody (HJ15.1)
Datasheets
InVivoMAb Anti-Human Apolipoprotein E/ApoE Antibody (HJ15.1).pdf