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Abinscience InVivoMAb Anti-Human CD37 Antibody (Iv0275) (HY564010-1mg)

Abinscience InVivoMAb Anti-Human CD37 Antibody (Iv0275) (HY564010-1mg)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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Product Details

Overview

Catalog No. HY564010-1mg
Description
Abinscience InVivoMAb Anti-Human CD37/TSPAN26 Antibody (Iv0275)[Iv0275] (HY564010-1mg) is a human monoclonal antibody detecting CD37 in ELISA, FCM, Neutralization, WB. Suitable for Human.
HIGHLIGHTS
  • ● Multi-Application — Validated across multiple applications.
  • ● Flow Cytometry — Validated for flow cytometry applications.
Species reactivity Human
Applications ELISA, FCM, Neutralization, WB
Host species Human
Isotype IgG1, kappa
Clone ID Iv0275
Clonality Monoclonal
Target CD37, Tspan-26, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P11049
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT.

1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718
2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544
3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550
Note For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE for InVivoMAb Anti-Human CD37/TSPAN26 Antibody (Iv0275)

Datasheets

InVivoMAb Anti-Human CD37 Antibody (Iv0275).pdf


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Abinscience InVivoMAb Anti-Human CD37 Antibody (Iv0275) (HY564010-1mg)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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