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Abinscience InVivoMAb Anti-Human Cannabinoid R1/CB1/CNR1 Antibody (5D12) (HB822010-1mg)
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Abinscience InVivoMAb Anti-Human Cannabinoid R1/CB1/CNR1 Antibody (5D12) (HB822010-1mg)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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Product Details

Overview

Catalog No. HB822010-1mg
Description
Abinscience InVivoMAb Anti-Human CNR1/CB1 Nanobody (5D12)[5D12] (HB822010-1mg) is a alpaca monoclonal antibody detecting CNR1 in ELISA, Neutralization. Suitable for Human.
Species reactivity Human
Applications ELISA, Neutralization, WB
Host species Alpaca
Isotype VHH-8His-Cys-tag
Clone ID 5D12
Clonality Monoclonal
Tested applications WB
Target CNR1, CB1, CANN6, CB-R, CNR, Cannabinoid receptor 1
Endotoxin level <0.01 EU/ug
Purity >95% as determined by SDS-PAGE.
Associated products pH 7.4 Dilution Buffer
Purification Purified by Nickel column.
Accession P21554
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Cannabinoid receptor 1 (CNR1/CB1) is a ~52 kDa protein. G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses.

1. Ryberg, E. et al. (2005) FEBS letters 579, 259-64. PMID: 15620723
2. Hua, T. et al. (2016) Cell 167, 750-762.e14. PMID: 27768894
3. Shao, Z. et al. (2016) Nature 540, 602-606. PMID: 27851727
4. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350
5. Gérard, CM. et al. (1991) The Biochemical journal 279 ( Pt 1), 129-34. PMID: 1718258
6. Oddi, S. et al. (2012) British journal of pharmacology 165, 2635-51. PMID: 21895628
7. Niehaus, JL. et al. (2007) Molecular pharmacology 72, 1557-66. PMID: 17895407
8. Jourdan, T. et al. (2013) Nature medicine 19, 1132-40. PMID: 23955712
Note For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE for InVivoMAb Anti-Human CNR1/CB1 Nanobody (5D12)

Detects recombinant CNR1 (Catalog No: HB822012) in indirect ELISA.

Western blot analysis was performed using anti-CNR1 monoclonal antibody at 1ug/mL on various samples.

Lane 1: recombinant human CNR1 (Catalog No: HB822012)

Datasheets

InVivoMAb Anti-Human Cannabinoid R1/CB1/CNR1 Antibody (5D12).pdf



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Abinscience InVivoMAb Anti-Human Cannabinoid R1/CB1/CNR1 Antibody (5D12) (HB822010-1mg)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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