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Abinscience InVivoMAb Anti-Human ROR1 Antibody (2A2) (HX065010-100ug)

Abinscience InVivoMAb Anti-Human ROR1 Antibody (2A2) (HX065010-100ug)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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Product Details

Overview

Catalog No. HX065010-100ug
Description
Abinscience InVivoMAb Anti-Human ROR1/NTRKR1 Antibody (2A2)[2A2] (HX065010-100ug) is a human monoclonal antibody detecting Neurotrophic tyrosine kinase in ELISA, FCM, Neutralization. Suitable for Human.
HIGHLIGHTS
  • ● Multi-Application — Validated across multiple applications.
  • ● Flow Cytometry — Validated for flow cytometry applications.
Species reactivity Human
Applications ELISA, FCM, Neutralization
Host species Human
Isotype IgG1, kappa
Clone ID 2A2
Clonality Monoclonal
Target Neurotrophic tyrosine kinase, receptor-related 1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, ROR1
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession Q01973
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Inactive tyrosine-protein kinase transmembrane receptor ROR1 (NTRKR1) is a ~104 kDa protein. Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling.

1. Bainbridge, TW. et al. (2014) PloS one 9, e102695. PMID: 25029443
2. Diaz-Horta, O. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 5993-8. PMID: 27162350
3. Lin, W. et al. (2023) Nature communications 14, 1578. PMID: 36949068
Note For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE for InVivoMAb Anti-Human ROR1/NTRKR1 Antibody (2A2)

Datasheets

InVivoMAb Anti-Human ROR1 Antibody (2A2).pdf

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Abinscience InVivoMAb Anti-Human ROR1 Antibody (2A2) (HX065010-100ug)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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