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Abinscience InVivoMAb Anti-Human TREM2 Antibody (42E8#) (HV166010-100ug)
Overview
| Catalog No. | HV166010-100ug |
|---|---|
| Description | Abinscience InVivoMAb Anti-Human TERM2 Antibody (42E8#)[42E8#] (HV166010-100ug) is a human monoclonal
antibody detecting Triggering receptor expressed on myeloid cells 2
in Agonist, ELISA. Suitable for Human.
|
| Species reactivity | Human |
| Applications | Agonist, ELISA |
| Host species | Human |
| Isotype | IgG1 |
| Clone ID | 42E8# |
| Clonality | Monoclonal |
| Target | Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, TREM2 |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | Q9NZC2 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Triggering receptor expressed on myeloid cells 2 (TERM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849
2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018
3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356
4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134
5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881
6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066
7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640
8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Human TERM2 Antibody (42E8#).