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Abinscience InVivoMAb Anti-Human Transglutaminase 2/TGM2 Antibody (52F3) (HB247010-50ug)
Overview
| Catalog No. | HB247010-50ug |
|---|---|
| Description | Abinscience InVivoMAb Anti-Human TGM2 Antibody (52F3)[52F3] (HB247010-50ug) is a human monoclonal
antibody detecting Protein-glutamine deamidase TGM2
in Blocking, ELISA, FCM, SPR. Suitable for Human.
HIGHLIGHTS
|
| Species reactivity | Human |
| Applications | Blocking, ELISA, FCM, SPR |
| Host species | Human |
| Isotype | IgG4, kappa |
| Clone ID | 52F3 |
| Clonality | Monoclonal |
| Target | Protein-glutamine deamidase TGM2, TGase II, Heart G alpha(h), Erythrocyte transglutaminase, Protein-glutamine gamma-glutamyltransferase 2, TG(C), Transglutaminase C, Protein-glutamine serotonyltransferase TGM2, tTG, tTgase, Transglutaminase-2, Protein-glutamine noradrenalinyltransferase TGM2, TGM2, TG2, TGase C, Protein G alpha(h), Protein-glutamine histaminyltransferase TGM2, Tissue transglutaminase, hhG alpha(h), G(h), hTG2, Transglutaminase H, Protein-glutamine dopaminyltransferase TGM2, TGC, Isopeptidase TGM2, TGase-2, TGase H, Transglutaminase II |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P21980 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. 1. Kanchan, K. et al. (2013) The Biochemical journal 455, 261-72. PMID: 23941696
2. Jeong, EM. et al. (2020) International journal of molecular sciences 21. PMID: 31991788
3. Nemes, Z. et al. (1997) The Journal of biological chemistry 272, 20577-83. PMID: 9252372
4. Upchurch, HF. et al. (1991) Journal of cellular physiology 149, 375-82. PMID: 1683874
5. Lai, TS. et al. (2017) Amino acids 49, 501-515. PMID: 27270573
6. Hernandez-Fernaud, JR. et al. (2017) Nature communications 8, 14206. PMID: 28198360
7. Melino, G. et al. (1994) Molecular and cellular biology 14, 6584-96. PMID: 7935379
8. Hsieh, YF. et al. (2013) PloS one 8, e81516. PMID: 24349085
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE for InVivoMAb Anti-Human TGM2 Antibody (52F3).
Datasheets
InVivoMAb Anti-Human Transglutaminase 2/TGM2 Antibody (52F3).pdf