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Abinscience InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284) (MB978010-100ug)
Overview
| Catalog No. | MB978010-100ug |
|---|---|
| Description | Abinscience InVivoMAb Anti-Mouse IL11 Antibody (Iv0284)[Iv0284] (MB978010-100ug) is a mouse monoclonal
antibody detecting Interleukin-11
in ELISA, FCM, Neutralization, WB, in vivo research. Suitable for Mouse.
HIGHLIGHTS
|
| Species reactivity | Mouse |
| Applications | ELISA, FCM, Neutralization, WB, in vivo research |
| Host species | Mouse |
| Isotype | IgG2a, kappa |
| Clone ID | Iv0284 |
| Clonality | Monoclonal |
| Target | Interleukin-11, IL-11, Il11 |
| Endotoxin level | < 10 EU/mg |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P47873 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Morris, JC. et al. (1996) Experimental hematology 24, 1369-76. PMID: 8913282
2. Nishina, T. et al. (2012) Science signaling 5, ra5. PMID: 22253262
3. Barton, VA. et al. (1999) The Journal of biological chemistry 274, 5755-61. PMID: 10026196
4. Putoczki, TL. et al. (2013) Cancer cell 24, 257-71. PMID: 23948300
|
| Note | For research use only. |
Images
SDS-PAGE for InVivoMAb Anti-Mouse IL11 Antibody (Iv0284)