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Abinscience InVivoMAb Anti-Mouse IL-6R alpha/IL6R Antibody (15A7) (MY583010-100ug)

Abinscience InVivoMAb Anti-Mouse IL-6R alpha/IL6R Antibody (15A7) (MY583010-100ug)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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Product Details

Overview

Catalog No. MY583010-100ug
Description
Abinscience InVivoMAb Anti-Mouse IL6R (15A7)[15A7] (MY583010-100ug) is a rat monoclonal antibody detecting Interleukin-6 receptor subunit alpha in ELISA, FACS, Functional assay, Research in vivo. Suitable for Mouse.
HIGHLIGHTS
  • ● Multi-Application — Validated across multiple applications.
Species reactivity Mouse
Applications ELISA, FACS, Functional assay, Research in vivo
Host species Rat
Isotype IgG2b, kappa
Clone ID 15A7
Clonality Monoclonal
Target Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80, gp80, CD126, Soluble interleukin-6 receptor subunit alpha, sIL6R, IL6R
Endotoxin level < 10 EU/mg
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P08887
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Product Usage Information
Application Dilution
ELISA 1:2000-1:20000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Interleukin-6 receptor subunit alpha (IL6R) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.

1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003
2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492
3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509
Note For research use only.

Images

SDS-PAGE for InVivoMAb Anti-Mouse IL6R (15A7)

Datasheets

InVivoMAb Anti-Mouse IL-6R alpha/IL6R Antibody (15A7).pdf

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Abinscience InVivoMAb Anti-Mouse IL-6R alpha/IL6R Antibody (15A7) (MY583010-100ug)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies / InVivoMAb
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