Adenosine A2A-R Polyclonal Antibody, 100μg, (ATB-T0130)

Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]Product datasheet: Overview Product Description Adenosine A2A-R Polyclonal Antibody, 100μg, (ATB-T0130) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human Adenosine A2A-R. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia. Villar-Menéndez I, et al. J Psychiatr Res, 2014 Apr. PMID 24433848 Bridging molecular docking to membrane molecular dynamics to investigate GPCR-ligand recognition: the human A₂A adenosine receptor as a key study. Sabbadin D, et al. J Chem Inf Model, 2014 Jan 27. PMID 24359090 Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. Gussago C, et al. J Alzheimers Dis, 2014. PMID 24321892 Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease. Piersanti G, et al. J Med Chem, 2013 Jul 11. PMID 23789814 Adenosine A2A receptors in secondary progressive multiple sclerosis: a [(11)C]TMSX brain PET study. Rissanen E, et al. J Cereb Blood Flow Metab, 2013 Sep. PMID 23695433 Free PMC Article