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Adenosine A3-R Polyclonal Antibody, 100μg, (ATB-T0132)

$199.00
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Product Details

Background: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]Product datasheet: Overview Product Description Adenosine A3-R Polyclonal Antibody, 100μg, (ATB-T0132) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human Adenosine A3-R. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Activation of adenosine A3 receptor alleviates TNF-α-induced inflammation through inhibition of the NF-κB signaling pathway in human colonic epithelial cells. Ren T, et al. Mediators Inflamm, 2014. PMID 24864134 Free PMC Article Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch. Dal Ben D, et al. Biochem Pharmacol, 2014 Jan 15. PMID 24161786 Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome. Campbell NG, et al. Mol Autism, 2013 Aug 16. PMID 23953133 Free PMC Article Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. Corriden R, et al. EMBO Rep, 2013 Aug. PMID 23817552 Free PMC Article Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. Vincenzi F, et al. PLoS One, 2013. PMID 23741498 Free PMC Article

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Adenosine A3-R Polyclonal Antibody, 100μg, (ATB-T0132)
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