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Akt2 Polyclonal Antibody, 100μg, (ATB-T0187)

$199.00
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Background: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Akt2 Polyclonal Antibody, 100μg, (ATB-T0187) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Akt2 around the non-phosphorylation site of S474. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: AKT2 expression in histopathologic grading and recurrence of meningiomas. Wang Q, et al. Eur J Surg Oncol, 2014 Sep. PMID 24656454 Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells. Villegas-Comonfort S, et al. Prostaglandins Leukot Essent Fatty Acids, 2014 May. PMID 24565443 Akt2 regulates metastatic potential in neuroblastoma. Qiao J, et al. PLoS One, 2013. PMID 23468863 Free PMC Article Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition. Choi KY, et al. J Cell Physiol, 2013 Apr. PMID 23018889 Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Martin VA, et al. Cell Signal, 2012 May. PMID 22261254 Free PMC Article

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Akt2 Polyclonal Antibody, 100μg, (ATB-T0187)
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