Annexin I Polyclonal Antibody, 100µg, (ATB-T0234)

Background: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.Product datasheet: Overview Product Description Annexin I Polyclonal Antibody, 100µg, (ATB-T0234) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Annexin I. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Wallner B.P., Mattaliano R.J., Hession C., Cate R.L., Tizard R., Sinclair L.K., Foeller C., Chow E.P., Browning J.L., Ramachandran K.L., Pepinsky R.B.Nature 320:77-81(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Correlation of gene and protein structure of rat and human lipocortin I. Kovacic R.T., Tizard R., Cate R.L., Frey A.Z., Wallner B.P.Biochemistry 30:9015-9021(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. Arcone R., Arpaia G., Ruoppolo M., Malorni A., Pucci P., Marino G., Ialenti A., di Rosa M., Ciliberto G.Eur. J. Biochem. 211:347-355(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Lung. Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. Varticovski L., Chahwala S.B., Whitman M., Cantley L., Schindler D., Chow E.P., Sinclair L.K., Pepinsky R.B.Biochemistry 27:3682-3690(1988) [PubMed] [Europe PMC] Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT TYR-21 BY EGFR AND SER-27 BY PKC. Characterization by tandem mass spectrometry of structural modifications in proteins. Biemann K., Scoble H.A.Science 237:992-998(1987) [PubMed] [Europe PMC] Cited for: ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY. A dimeric form of lipocortin-1 in human placenta. Pepinsky R.B., Sinclair L.K., Chow E.P., O'Brine-Greco B.Biochem. J. 263:97-103(1989) [PubMed] [Europe PMC] Cited for: DIMERIZATION. Phosphorylation of annexin I by TRPM7 channel-kinase. Dorovkov M.V., Ryazanov A.G.J. Biol. Chem. 279:50643-50646(2004) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT SER-5 BY TRPM7. A quantitative atlas of mitotic phosphorylation. Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) [PubMed] [Europe PMC] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-239 AND LYS-312, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].