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Annexin VI Polyclonal Antibody, 100μg, (ATB-T0238)

$199.00
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Product Details

Background: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]Product datasheet: Overview Product Description Annexin VI Polyclonal Antibody, 100μg, (ATB-T0238) Image Species Reactivities Human Immunogen Synthesized peptide derived from the N-terminal region of human Annexin VI. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Annexin A6-balanced late endosomal cholesterol controls influenza A replication and propagation. Musiol A, et al. MBio, 2013 Nov 5. PMID 24194536 Free PMC Article Influence of the 524-VAAEIL-529 sequence of annexins A6 in their interfacial behavior and interaction with lipid monolayers. Domon MM, et al. J Colloid Interface Sci, 2013 Aug 1. PMID 23683957 Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling. Cornely R, et al. IUBMB Life, 2011 Nov. PMID 21990038 Annexin A6 is recruited into lipid rafts of Niemann-Pick type C disease fibroblasts in a Ca2+-dependent manner. Domon MM, et al. Biochem Biophys Res Commun, 2011 Feb 11. PMID 21216236 Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions. Sakwe AM, et al. Exp Cell Res, 2011 Apr 1. PMID 21185831 Free PMC Article

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Annexin VI Polyclonal Antibody, 100μg, (ATB-T0238)
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