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Annexin VII Polyclonal Antibody, 100μg, (ATB-T15373)
Background: Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Annexin VII Polyclonal Antibody, 100μg, (ATB-T15373) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human Annexin VII. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. Ferrarese R, et al. J Clin Invest, 2014 Jul. PMID 24865424 Free PMC Article Identification of a small molecule targeting annexin A7. Li H, et al. Biochim Biophys Acta, 2013 Sep. PMID 23651924 Down-regulation of ANXA7 decreases metastatic potential of human hepatocellular carcinoma cells in vitro. Ibrahim MM, et al. Biomed Pharmacother, 2013 May. PMID 23582794 Arthritogenicity of annexin VII revealed by phosphoproteomics of rheumatoid synoviocytes. Matsuo K, et al. Ann Rheum Dis, 2011 Aug. PMID 21586441 Increased expression of annexin A7 in temporal lobe tissue of patients with refractory epilepsy. Zhou SN, et al. Histol Histopathol, 2011 May. PMID 21432772
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At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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- Protective gear
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