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Anti-Human Heparanase Neutralizing Recombinant Antibody (A54) (HC115013-50ug)
Overview
| Catalog No. | HC115013-50ug | ||||
|---|---|---|---|---|---|
| Species reactivity | Human | ||||
| Applications | ELISA, Nneutralization, in vivo study | ||||
| Host species | Mouse | ||||
| Isotype | IgG | ||||
| Clone ID | A54 | ||||
| Clonality | Monoclonal | ||||
| Target | Heparanase, EC:3.2.1.166, Endo-glucoronidase, Heparanase-1, Hpa1, Heparanase 8 kDa subunit, Heparanase 50 kDa subunit, HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1 | ||||
| Endotoxin level | Please contact with the lab for this information. | ||||
| Purity | >95% as determined by SDS-PAGE. | ||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||
| Accession | Q9Y251 | ||||
| Form | Liquid | ||||
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Background | Heparanase is a ~61 kDa protein. Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. |
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| Note | For research use only |
Images
SDS-PAGE for Anti-Human Heparanase Neutralizing Antibody (A54)
Datasheets
Anti-Human Heparanase Neutralizing Recombinant Antibody (A54).pdf