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ApoA-V Polyclonal Antibody, 100μg, (ATB-T0269)

$199.00
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Product Details

Background: The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]Product datasheet: Overview Product Description ApoA-V Polyclonal Antibody, 100μg, (ATB-T0269) Image Species Reactivities Human Immunogen Synthesized peptide derived from the N-terminal region of human ApoA-V. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). Sharma V, et al. Arterioscler Thromb Vasc Biol, 2014 Oct. PMID 25127531 Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents. Zhu WF, et al. Lipids Health Dis, 2014 Jun 5. PMID 24903888 Free PMC Article Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism. Kim M, et al. Nutr J, 2014 Apr 28. PMID 24775272 Free PMC Article Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 diabetes. Kang R, et al. Trials, 2014 Apr 1. PMID 24690159 Free PMC Article Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients. Ouatou S, et al. Lipids Health Dis, 2014 Apr 1. PMID 24684850 Free PMC Article

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ApoA-V Polyclonal Antibody, 100μg, (ATB-T0269)
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