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ApoE Polyclonal Antibody, 100μg, (ATB-T0274)

$199.00
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Background: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]Product datasheet: Overview Product Description ApoE Polyclonal Antibody, 100μg, (ATB-T0274) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human ApoE. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Apolipoprotein E genotype has a modest impact on the postprandial plasma response to meals of varying fat composition in healthy men in a randomized controlled trial. Calabuig-Navarro MV, et al. J Nutr, 2014 Nov. PMID 25332476 Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. Knoferle J, et al. J Neurosci, 2014 Oct 15. PMID 25319703 Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice. Zerbi V, et al. J Neurosci, 2014 Oct 15. PMID 25319693 Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. Gaynor JW, et al. J Thorac Cardiovasc Surg, 2014 Dec. PMID 25282659 APOE ε variants increase risk of warfarin-related intracerebral hemorrhage. Falcone GJ, et al. Neurology, 2014 Sep 23. PMID 25150286

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ApoE Polyclonal Antibody, 100μg, (ATB-T0274)
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