C/EBP-ε (Phospho-Thr74) Rabbit Polyclonal Antibody, 100 ug

Background: The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Product datasheet: Overview Product Description C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Tested Applications WB Image Western blot analysis of extracts from HUVEC cells treated with UV using C/EBP- (Phospho-Thr74) Antibody #11686.The lane on the right is treated with the antigen-specific peptide. Species Reactivities Human Immunogen Peptide sequence around phosphorylation site of threonine 174 (L-A-T(p)-A-A) derived from Human C/EBP-. Properties Storage Instructions Store at -20C Clonality Polyclonal Antibody References: A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBP Leads to Neutrophil-Specific Granule Deficiency. Wada T, et al. J Immunol, 2015 Jul 1. PMID 26019275 Acetylation of C/EBP is a prerequisite for terminal neutrophil differentiation. Bartels M, et al. Blood, 2015 Mar 12. PMID 25568349 CEBPE polymorphism confers an increased risk of childhood acute lymphoblastic leukemia: a meta-analysis of 11 case-control studies with 5,639 cases and 10,036 controls. Wang C, et al. Ann Hematol, 2015 Feb. PMID 25195121 Identification of functional nucleotide and haplotype variants in the promoter of the CEBPE gene. Ryoo H, et al. J Hum Genet, 2013 Sep. PMID 23719191 Double CEBPE-IGH rearrangement due to chromosome duplication and cryptic insertion in an adult with B-cell acute lymphoblastic leukemia. Pierini V, et al. Cancer Genet, 2011 Oct. PMID 22137487 A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. Antonson P., Stellan B., Yamanaka R., Xanthopoulos K.G. Genomics 35:30-38(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. Chumakov A.M., Grillier I., Chumakova E., Chih D., Slater J., Koeffler H.P. Mol. Cell. Biol. 17:1375-1386(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.