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C1s Polyclonal Antibody, 100μg, (ATB-T0567)

$199.00
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Background: This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]Product datasheet: Overview Product Description C1s Polyclonal Antibody, 100μg, (ATB-T0567) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human C1s. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. Shi J, et al. Blood, 2014 Jun 26. PMID 24695853 Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice. Tamura K, et al. Nephron Exp Nephrol, 2013. PMID 23989031 Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. Duncan RC, et al. J Immunol, 2012 Sep 1. PMID 22855709 Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene. Amano MT, et al. Mol Immunol, 2008 Mar. PMID 18062908 Elucidation of the substrate specificity of the C1s protease of the classical complement pathway. Kerr FK, et al. J Biol Chem, 2005 Nov 25. PMID 16169853

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C1s Polyclonal Antibody, 100μg, (ATB-T0567)
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