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CD110 Polyclonal Antibody, 100μg, (ATB-T0718)
Background: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CD110 Polyclonal Antibody, 100μg, (ATB-T0718) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CD110. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. Hirata S, et al. J Clin Invest, 2013 Sep. PMID 23908116 Free PMC Article Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasms. Rumi E, et al. Blood, 2013 May 23. PMID 23575445 Free PMC Article MPL Baltimore mutation and thrombocytosis: case report and literature review. Shkalim-Zemer V, et al. J Pediatr Hematol Oncol, 2013 Apr. PMID 23511495 MPL W515L mutation in pediatric essential thrombocythemia. Farruggia P, et al. Pediatr Blood Cancer, 2013 Aug. PMID 23441089 Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases. He X, et al. J Hematol Oncol, 2013 Jan 25. PMID 23351976 Free PMC Article
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