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CD159a/c Polyclonal Antibody, 100μg, (ATB-T15288)
Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]Product datasheet: Overview Product Description CD159a/c Polyclonal Antibody, 100μg, (ATB-T15288) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CD159a/c. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti-CD3 antibody. Ablamunits V, et al. Eur J Immunol, 2011 Jul. PMID 21538351 Free PMC Article NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. Béziat V, et al. PLoS One, 2010 Aug 6. PMID 20700504 Free PMC Article Association of NKG2A with treatment for chronic hepatitis C virus infection. Harrison RJ, et al. Clin Exp Immunol, 2010 Aug. PMID 20550548 Free PMC Article Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors. El Costa H, et al. J Reprod Immunol, 2009 Nov. PMID 19615756 Permanent silencing of NKG2A expression for cell-based therapeutics. Figueiredo C, et al. J Mol Med (Berl), 2009 Feb. PMID 19002424
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