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CD169 Polyclonal Antibody, 100μg, (ATB-T15399)

$199.00
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Background: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CD169 Polyclonal Antibody, 100μg, (ATB-T15399) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CD169. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Increased expression of Siglec-1 on peripheral blood monocytes and its role in mononuclear cell reactivity to autoantigen in rheumatoid arthritis. Xiong YS, et al. Rheumatology (Oxford), 2014 Feb. PMID 24196391 CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma. Ohnishi K, et al. Cancer Sci, 2013 Sep. PMID 23734742 Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. Puryear WB, et al. PLoS Pathog, 2013. PMID 23593001 Free PMC Article Increased monocyte expression of sialoadhesin during acute cellular rejection and other enteritides after intestine transplantation in children. Ashokkumar C, et al. Transplantation, 2012 Mar 15. PMID 22249367 Increased Siglec-1 expression in monocytes of patients with primary biliary cirrhosis. Bao G, et al. Immunol Invest, 2010. PMID 20653431

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CD169 Polyclonal Antibody, 100μg, (ATB-T15399)
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