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CD1E Polyclonal Antibody, 100μg, (ATB-T15240)
Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]Product datasheet: Overview Product Description CD1E Polyclonal Antibody, 100μg, (ATB-T15240) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human CD1E. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Fine tuning by human CD1e of lipid-specific immune responses. Facciotti F, et al. Proc Natl Acad Sci U S A, 2011 Aug 23. PMID 21844346 Free PMC Article Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes. Garcia-Alles LF, et al. Proc Natl Acad Sci U S A, 2011 Aug 9. PMID 21788486 Free PMC Article Increased flexibility and liposome-binding capacity of CD1e at endosomal pH. Bushmarina N, et al. FEBS J, 2011 Jun. PMID 21481186 The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments. Maître B, et al. Biochem J, 2009 May 1. PMID 19196239 Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation. Tourne S, et al. J Immunol, 2008 Mar 15. PMID 18325888
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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