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CD241 Polyclonal Antibody, 100μg, (ATB-T15284)

$199.00
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Product Details

Background: The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]Product datasheet: Overview Product Description CD241 Polyclonal Antibody, 100μg, (ATB-T15284) Image Species Reactivities Human Immunogen Synthesized peptide derived from the N-terminal region of human CD241. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Human RhAG ammonia channel is impaired by the Phe65Ser mutation in overhydrated stomatocytic red cells. Genetet S, et al. Am J Physiol Cell Physiol, 2012 Jan 15. PMID 22012326 Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Stewart AK, et al. Am J Physiol Cell Physiol, 2011 Dec. PMID 21849667 Free PMC Article A family study of the Chinese Rhnull individual of the regulator type: a novel single missense mutation identified in RHAG gene. Tian L, et al. Transfusion, 2011 Dec. PMID 21682734 The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein. Bruce LJ, et al. Blood, 2009 Feb 5. PMID 18931342 RhAG protein of the Rhesus complex is a CO2 channel in the human red cell membrane. Endeward V, et al. FASEB J, 2008 Jan. PMID 17712059

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CD241 Polyclonal Antibody, 100μg, (ATB-T15284)
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