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CD276 Polyclonal Antibody, 100μg, (ATB-T15285)

$199.00
In stock
Product Details

Background: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]Product datasheet: Overview Product Description CD276 Polyclonal Antibody, 100μg, (ATB-T15285) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human CD276. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: [Single nucleotide polymorphisms of B7-H3 gene in blood cells of patients with rheumatoid arthritis]. Sun J, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2014 Sep. PMID 25200161 [Plasma sB7-H3 serves as an assistant diagnostic marker for hepatitis B virus-associated hepatocellular carcinoma]. Xu W, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2014 Jul. PMID 25001942 Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. Kraan J, et al. Br J Cancer, 2014 Jul 8. PMID 24892449 B7-H3 was highly expressed in human primary hepatocellular carcinoma and promoted tumor progression. Wang F, et al. Cancer Invest, 2014 Jul. PMID 24787022 Characterization of a soluble B7-H3 (sB7-H3) spliced from the intron and analysis of sB7-H3 in the sera of patients with hepatocellular carcinoma. Chen W, et al. PLoS One, 2013. PMID 24194851 Free PMC Article

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CD276 Polyclonal Antibody, 100μg, (ATB-T15285)
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