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CD294 Polyclonal Antibody, 100μg, (ATB-T15405)

$199.00
In stock
Product Details

Background: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]Product datasheet: Overview Product Description CD294 Polyclonal Antibody, 100μg, (ATB-T15405) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human CD294. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Opposing roles of prostaglandin D2 receptors in ulcerative colitis. Sturm EM, et al. J Immunol, 2014 Jul 15. PMID 24929001 Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. Sykes L, et al. PLoS One, 2012. PMID 23226366 Free PMC Article The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Campos Alberto E, et al. Allergy, 2012 Nov. PMID 22947041 Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. Yue L, et al. Bone, 2012 Sep. PMID 22705147 Roles of CRTH2+ CD4+ T cells in immunoglobulin G4-related lacrimal gland enlargement. Saito Y, et al. Int Arch Allergy Immunol, 2012. PMID 22627365

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CD294 Polyclonal Antibody, 100μg, (ATB-T15405)
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