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CD3 ζ Polyclonal Antibody, 100μg, (ATB-T0747)

$199.00
In stock
Product Details

Background: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CD3 ζ Polyclonal Antibody, 100μg, (ATB-T0747) Image Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from human CD3 ζ around the non-phosphorylation site of Y142. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR ζ chain expression on CD8(+) T cells in chronic hepatitis C patients. Zeng QL, et al. Mol Cells, 2014 Jan. PMID 24552712 Free PMC Article Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis. Teruel M, et al. PLoS One, 2013. PMID 23861880 Free PMC Article CD247 variants and single-nucleotide polymorphisms observed in systemic lupus erythematosus patients. Takeuchi T, et al. Rheumatology (Oxford), 2013 Sep. PMID 23525753 Upregulated TCRζ enhances interleukin-2 production in T-cells from patients with CML. Zha X, et al. DNA Cell Biol, 2012 Nov. PMID 23057733 Free PMC Article CD3Z genetic polymorphism in immune response to hepatitis B vaccination in two independent Chinese populations. Pan LP, et al. PLoS One, 2012. PMID 22536368 Free PMC Article

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CD3 ζ Polyclonal Antibody, 100μg, (ATB-T0747)
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