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CD300f Polyclonal Antibody, 100μg, (ATB-T15475)

$199.00
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Product Details

Background: This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]Product datasheet: Overview Product Description CD300f Polyclonal Antibody, 100μg, (ATB-T15475) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CD300f. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. Izawa K, et al. J Allergy Clin Immunol, 2014 Jan. PMID 24035150 Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury. Peluffo H, et al. Brain Pathol, 2012 May. PMID 21951326 The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. Alvarez-Errico D, et al. J Immunol, 2007 Jan 15. PMID 17202342 Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K. Lee SM, et al. Clin Exp Immunol, 2012 Mar. PMID 22288587 Free PMC Article Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK). Lee SM, et al. Clin Exp Immunol, 2010 Sep. PMID 20646006 Free PMC Article

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CD300f Polyclonal Antibody, 100μg, (ATB-T15475)
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