CD314 Polyclonal Antibody, 100μg, (ATB-T0753)

Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]Product datasheet: Overview Product Description CD314 Polyclonal Antibody, 100μg, (ATB-T0753) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CD314. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D. Hagemann-Jensen M, et al. J Biol Chem, 2014 Nov 7. PMID 25258323 A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function. Karimi MA, et al. J Immunol, 2014 Sep 15. PMID 25092887 CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation. Ruck T, et al. PLoS One, 2013. PMID 24282598 Free PMC Article NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp. Serrano-Pertierra E, et al. J Leukoc Biol, 2014 Mar. PMID 24168855 Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells. El-Gazzar A, et al. Oncogene, 2014 Oct 9. PMID 24141776