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CD316 Polyclonal Antibody, 100μg, (ATB-T15482)

$199.00
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Product Details

Background: This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]Product datasheet: Overview Product Description CD316 Polyclonal Antibody, 100μg, (ATB-T15482) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human CD316. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Kolesnikova TV, et al. Neoplasia, 2009 Jan. PMID 19107234 Free PMC Article EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Charrin S, et al. Biochem J, 2003 Jul 15. PMID 12708969 Free PMC Article EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry. Potel J, et al. Cell Microbiol, 2013 Jul. PMID 23351194 EWI-2 association with α-actinin regulates T cell immune synapses and HIV viral infection. Gordón-Alonso M, et al. J Immunol, 2012 Jul 15. PMID 22689882 Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection. Montpellier C, et al. J Biol Chem, 2011 Apr 22. PMID 21343309 Free PMC Article

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CD316 Polyclonal Antibody, 100μg, (ATB-T15482)
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