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CD6 Polyclonal Antibody, 100μg, (ATB-T0771)

$199.00
In stock
Product Details

Background: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]Product datasheet: Overview Product Description CD6 Polyclonal Antibody, 100μg, (ATB-T0771) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CD6. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Identification of functionally relevant phoshorylatable serine clusters in the cytoplasmic region of the human CD6 lymphocyte surface receptor. Bonet L, et al. FEBS Lett, 2013 Jul 11. PMID 23711376 Fine mapping and functional analysis of the multiple sclerosis risk gene CD6. Swaminathan B, et al. PLoS One, 2013. PMID 23638056 Free PMC Article The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. Kofler DM, et al. J Immunol, 2011 Sep 15. PMID 21849685 Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome. Alonso R, et al. J Autoimmun, 2010 Dec. PMID 20810246 Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Alonso R, et al. Hybridoma (Larchmt), 2008 Aug. PMID 18707547

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CD6 Polyclonal Antibody, 100μg, (ATB-T0771)
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